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MET and RON receptor tyrosine kinases in colorectal adenocarcinoma

by Shuan | Posted on

MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular choices as targets and antibody conjugates for treatment

 

Superior colorectal adenocarcinoma (CRAC), featured by distinctive histopathological look, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a bunch of heterogeneous cancers with distinctive genetic signatures and malignant phenotypes. Remedy of CRAC is a daunting exercise for oncologists.

 

In the mean time, quite a few strategies along with molecular specializing in using therapeutic monoclonal antibodies, small molecule kinase inhibitors and immunoregulatory checkpoint treatment have been utilized to struggle this deadly sickness. However, these therapeutic modalities and approaches acquire solely restricted success. Thus, there is a pharmaceutical wish to discover new targets and develop novel therapeutics for CRAC treatment. MET and RON receptor tyrosine kinases have been implicated in CRAC pathogenesis.

 

Scientific analysis have revealed that aberrant MET and/or RON expression and signaling are important in regulating CRAC growth and malignant phenotypes. Elevated MET and/or RON expression moreover has prognostic price for CRAC growth and affected individual survival.

 

These choices current the rationale to deal with MET and RON for scientific CRAC intervention. At present, utilizing small molecule kinase inhibitors specializing in MET for CRAC remedy has achieved very important progress with a variety of approvals for scientific utility.

 

Nonetheless, antibody-based biotherapeutics, although beneath scientific trials for larger than Eight years, have made little or no progress. On this evaluation, we deal with the importance of MET and/or RON in CRAC tumorigenesis and progress of anti-MET, anti-RON, and MET and RON-dual specializing in antibody conjugates for scientific utility. The findings from every preclinical analysis and scientific trials highlight the potential of this novel form of biotherapeutics for CRAC treatment ultimately.

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Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2C2 (formerly 2C2)
TA500955 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2C2 (formerly 2C2)
TA500955S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2G2 (formerly 2G2)
TA500956 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2G2 (formerly 2G2)
TA500956S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4C3 (formerly 4C3)
TA501021 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4C3 (formerly 4C3)
TA501021S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4H1 (formerly 4H1)
TA501044 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4H1 (formerly 4H1)
TA501044S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)
TA501045 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)
TA501045S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4A1 (formerly 4A1)
TA501046 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4A1 (formerly 4A1)
TA501046S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11A6 (formerly 11A6)
TA501076 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11A6 (formerly 11A6)
TA501076S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B6 (formerly 11B6)
TA501077 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B6 (formerly 11B6)
TA501077S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H5 (formerly 11H5)
TA501078 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H5 (formerly 11H5)
TA501078S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B5 (formerly 11B5)
TA501079 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B5 (formerly 11B5)
TA501079S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H6 (formerly 11H6)
TA501080 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H6 (formerly 11H6)
TA501080S 30 µl Ask for price

Mouse Monoclonal anti-human Orexin-B peptide
hAP-0501 100ug
EUR 250

Mouse Monoclonal anti-human Phosphotyrosine peptide
hAP-0637 100ug
EUR 250

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse)
4-MAA503Mu21
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB)

Anti-Natriuretic Peptide Receptor A (NPR1) Mouse Monoclonal Antibody [Clone ID: OTI7H7]
M01042 100ul
EUR 523
Description: Boster Bio NPR1 mouse monoclonal antibody, clone OTI7H7 (formerly 7H7). Catalog# M01042. Tested in WB. This antibody reacts with Human, Mouse, Rat.

C-Peptide (CP) Monoclonal Antibody
CAU29243-100ul 100ul
EUR 267.8

C-Peptide (CP) Monoclonal Antibody
CAU29243-200ul 200ul
EUR 334.3

C-Peptide (CP) Monoclonal Antibody
CAU30193-100ul 100ul
EUR 254.4

C-Peptide (CP) Monoclonal Antibody
CAU30193-200ul 200ul
EUR 317.5

C-Peptide (CP) Monoclonal Antibody
CAU30505-100ul 100ul
EUR 247.7

C-Peptide (CP) Monoclonal Antibody
CAU30505-200ul 200ul
EUR 309.1

C-Peptide (CP) Monoclonal Antibody
CAU30630-100ul 100ul
EUR 245.8

C-Peptide (CP) Monoclonal Antibody
CAU30630-200ul 200ul
EUR 306.6

C-Peptide (CP) Monoclonal Antibody
MBS2105042-INQUIRE INQUIRE Ask for price

Monoclonal Anti-Cytokeratin Peptide 7 Antibody Antibody
GWB-BBB023 0.1 mg Ask for price

Monoclonal Anti-Cytokeratin Peptide 18 Antibody Antibody
GWB-BBB025 0.1 mg Ask for price

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), APC
4-MAA503Mu21-APC
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with APC.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), Cy3
4-MAA503Mu21-Cy3
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with Cy3.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), HRP
4-MAA503Mu21-HRP
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with HRP.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), PE
4-MAA503Mu21-PE
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with PE.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), FITC
4-MAA503Mu21-FITC
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with FITC.

C-Type Natriuretic Peptide (CNP) Monoclonal Antibody
CAU30663-100ul 100ul
EUR 225.6

C-Type Natriuretic Peptide (CNP) Monoclonal Antibody
CAU30663-200ul 200ul
EUR 282.2

Anti-Cytokeratin Peptide 7 antibody (monoclonal)
MBS175076-01mg 0.1mg
EUR 450

Anti-Cytokeratin Peptide 7 antibody (monoclonal)
MBS175076-5x01mg 5x0.1mg
EUR 1870

Anti-Cytokeratin Peptide 18 antibody (monoclonal)
MBS175098-01mg 0.1mg
EUR 450

Anti-Cytokeratin Peptide 18 antibody (monoclonal)
MBS175098-5x01mg 5x0.1mg
EUR 1870

Mouse anti- Human Natriuretic peptides B(NPPB) monoclonal Antibody
MBS1494887-005mg 0.05mg
EUR 220

Mouse anti- Human Natriuretic peptides B(NPPB) monoclonal Antibody
MBS1494887-01mg 0.1mg
EUR 300

Mouse anti- Human Natriuretic peptides B(NPPB) monoclonal Antibody
MBS1494887-5x01mg 5x0.1mg
EUR 1350

Mouse Monoclonal Anti-Mouse/rat NOS-II/i-NOS peptide, ascites
INOS23-M 100 ul
EUR 578.4

Natriuretic Peptides B Mouse Monoclonal Antibody
E10G20491 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Natriuretic Peptides B Mouse Monoclonal Antibody
E10G20492 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Natriuretic Peptides B Mouse Monoclonal Antibody
E10G20493 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), APC-Cy7
4-MAA503Mu21-APC-Cy7
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with APC-Cy7.

Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MAA721Hu22 100ul
EUR 235

Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2111573-INQUIRE INQUIRE Ask for price

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), Biotinylated
4-MAA503Mu21-Biotin
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  • 100ul
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with Biotin.

Monoclonal Antibody to C-Peptide (CP)
MAA447Po21 100ul
EUR 279

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra21 100ul
EUR 258

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra22 100ul
EUR 256

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra23 100ul
EUR 264

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra24 100ul
EUR 264

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra28 100ul
EUR 265

Monoclonal Antibody to C-Peptide (CP)
MBS2025818-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to C-Peptide (CP)
MBS2111139-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to C-Peptide (CP)
MBS2111140-INQUIRE INQUIRE Ask for price

C-Peptide (CP) Monoclonal Antibody (Rat)
4-MAA447Ra21
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP)

C-Peptide (CP) Monoclonal Antibody (Rat)
4-MAA447Ra28
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP)

Natriuretic Peptide Receptor B (NPR2) mouse monoclonal antibody, clone 1E4, Purified
AM31118PU-N 50 µg Ask for price

C-Peptide (CP) Monoclonal Antibody (Human)
4-MAA447Po21
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  • 100ul
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP)

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-10mg 10mg
EUR 6785

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-15mg 15mg
EUR 9610

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-1mg 1mg
EUR 900

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-25mg 25mg
EUR 15015

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-5mg 5mg
EUR 3670

Mouse monoclonal anti-human Proteolipid protein peptide 139-151 IgG, aff pure
PLP139-M 100 ug
EUR 578.4

Natriuretic Peptide Receptor B (NPR2) (131-231) mouse monoclonal antibody, clone 2A6, Purified
AM31133PU-N 50 µg Ask for price

Anti-Cytokeratin Peptide 18 Antibody ( Monoclonal, CY-90)
Ab1037 100μ/Vial
EUR 0.1

Anti-Cytokerain Peptide 7 Antibody (Monoclonal,LDS-68)
Ab1041 100μ/Vial
EUR 0.1

Monoclonal RXRB Antibody (Hinge Peptide)
AMM02172G 0.05ml
EUR 580.8
Description: A Monoclonal antibody against Human RXRB (Hinge Peptide). The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P

Mouse Monoclonal Anti-Human Human Ki67 (Proliferation Marker) peptide IgG
KI672-M 100 ul
EUR 578.4

C-Peptide (CP) Monoclonal Antibody (Rat), PE
4-MAA447Ra21-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), PE
4-MAA447Ra28-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), APC
4-MAA447Ra21-APC
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Rat), Cy3
4-MAA447Ra21-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Rat), HRP
4-MAA447Ra21-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with HRP.

C-Peptide (CP) Monoclonal Antibody (Rat), APC
4-MAA447Ra28-APC
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Rat), Cy3
4-MAA447Ra28-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Rat), HRP
4-MAA447Ra28-HRP
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  • 100ul
  • 10ml
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with HRP.

C-Peptide (CP) Monoclonal Antibody (Human), PE
4-MAA447Po21-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), FITC
4-MAA447Ra21-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with FITC.

C-Peptide (CP) Monoclonal Antibody (Rat), FITC
4-MAA447Ra28-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with FITC.

C-Peptide (CP) Monoclonal Antibody (Human), APC
4-MAA447Po21-APC
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  • 100ul
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Human), Cy3
4-MAA447Po21-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Human), HRP
4-MAA447Po21-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with HRP.

Monoclonal Anti-Human/mouse/rat Insulin chain B peptide IgG, aff pure
INSB22-M 100 ul
EUR 578.4

C-Peptide (CP) Monoclonal Antibody (Human), FITC
4-MAA447Po21-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with FITC.

Mouse monoclonal C-peptide antibody
MBS5305826-1mg 1mg
EUR 975

Mouse monoclonal C-peptide antibody
MBS5305826-5x1mg 5x1mg
EUR 4240

Mouse monoclonal C-peptide antibody
MBS5305827-1mg 1mg
EUR 975

Mouse monoclonal C-peptide antibody
MBS5305827-5x1mg 5x1mg
EUR 4240

Mouse monoclonal C-peptide antibody
MBS5305828-1mg 1mg
EUR 975

Mouse monoclonal C-peptide antibody
MBS5305828-5x1mg 5x1mg
EUR 4240

PE-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2118361-INQUIRE INQUIRE Ask for price

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29254-100ul 100ul
EUR 201.6

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29254-200ul 200ul
EUR 252

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29496-100ul 100ul
EUR 236.2

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29496-200ul 200ul
EUR 295.7

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29531-100ul 100ul
EUR 215

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29531-200ul 200ul
EUR 268.8

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU30640-100ul 100ul
EUR 215

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU30640-200ul 200ul
EUR 268.8

APC-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2119705-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2121192-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2115673-INQUIRE INQUIRE Ask for price

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-10mg 10mg
EUR 5145

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-15mg 15mg
EUR 7215

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-1mg 1mg
EUR 710

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-25mg 25mg
EUR 11365

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-5mg 5mg
EUR 2755

Monoclonal Natriuretic Peptide Receptor C Antibody, Clone: 1748CT403.18.42
AMM02573G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human Natriuretic Peptide Receptor C. The antibodies are raised in Mouse and are from clone 1748CT403.18.42. This antibody is applicable in WB, E

Monoclonal Antibody to Amyloid Beta Peptide 142 (Ab142)
MBS2138814-INQUIRE INQUIRE Ask for price

FITC-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2114346-INQUIRE INQUIRE Ask for price

C-Peptide (CP) Monoclonal Antibody (Rat), Biotinylated
4-MAA447Ra21-Biotin
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  • 100ul
  • 10ml
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Biotin.

C-Peptide (CP) Monoclonal Antibody (Rat), Biotinylated
4-MAA447Ra28-Biotin
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  • 100ul
  • 10ml
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  • 20ul
Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Biotin.

Biotin-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2112771-INQUIRE INQUIRE Ask for price

C-Peptide (CP) Monoclonal Antibody (Human), Biotinylated
4-MAA447Po21-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with Biotin.

Mouse Monoclonal Anti-Human Beta Actin peptide (non-muscle) IgG-HRP Conjugate
ACTB12-HRP 100 ul
EUR 489.6

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Hu21 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Hu22 100ul
EUR 210

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Hu23 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Hu24 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Hu25 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Hu27 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Hu29 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Mi28 100ul
EUR 293

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Mu21 100ul
EUR 246

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Ra21 100ul
EUR 253

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MAA541Ra22 100ul
EUR 260

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2025727-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2085854-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2085855-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2138563-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2138564-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2138565-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2138566-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2138567-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)
MBS2111556-INQUIRE INQUIRE Ask for price

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
CAU29329-100ul 100ul
EUR 225.6

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
CAU29329-200ul 200ul
EUR 282.2

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
CAU30210-100ul 100ul
EUR 267.8

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
CAU30210-200ul 200ul
EUR 334.3

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
CAU30508-100ul 100ul
EUR 267.8

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
CAU30508-200ul 200ul
EUR 334.3

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
CAU30514-100ul 100ul
EUR 221.8

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
CAU30514-200ul 200ul
EUR 277.2

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody
MBS2032012-INQUIRE INQUIRE Ask for price

Mouse Monoclonal Anti-Human Myelin Oligodendrocyte Glycoprotein (35-55 aa) peptide IgG
MOG3555-M 100 ug
EUR 578.4

Antibody Response to Canine Parvovirus Vaccination in Canines with Hyperadrenocorticism Dealt with with Trilostane

 

  • It is unknown how canines with hyperadrenocorticism (HAC) reply to vaccination. This analysis measured antibodies in opposition to canine parvovirus (CPV) in canines with HAC dealt with with trilostane sooner than and after CPV vaccination, and in distinction the immune response to that from healthful canines. Eleven canines with HAC, and healthful age-matched administration canines (n = 31) obtained a modified-live CPV vaccine. Antibodies have been selected days 0, 7, and 28 by hemagglutination inhibition. Univariate analysis was used to match the immune response of canines with HAC and healthful canines.

 

  • Pre-vaccination antibodies (≥10) have been detected in 100% of canines with HAC (11/11; 95% CI: 70.0-100) and in 93.5% of healthful canines (29/31; 95% CI: 78.3-99.2). No ≥4-fold improve in antibody titer was observed in canines with HAC whereas in 22.6% of healthful canines, a ≥4-fold titer improve was observed (7/31; 95% CI: 11.1-40.1).

 

  • Light vaccine-associated antagonistic events (VAAEs) have been detected in 54.5% of canines with HAC (6/11; 95% CI: 28.0-78.8) and in 29.0% of healthful canines (9/31; 95% CI: 15.9-46.8). There was neither a very important distinction in presence of pre-vaccination antibodies (p = 1.000), or response to vaccination (p = 0.161), nor throughout the prevalence of VAAEs (p = 0.158). Immune carry out of canines with HAC dealt with with trilostane seems much like that of healthful canines.

 

Design and Validation of Linkers for Web site-Explicit Preparation of Antibody Conjugates Carrying A lot of  Copies Per Cysteine Conjugation Web site

 

First-generation cysteine-based site-specific antibody conjugates (ADCs) are restricted to 1  per cysteine. However, positive functions require a extreme  to antibody ratio (DAR), comparable to when low-potency payloads are used. Elevated  load could also be achieved using classical cysteine conjugation methods, nevertheless these result in heterogeneity, suboptimal efficacy and pharmacokinetics.

 

Proper right here, we describe the design, synthesis and validation of heterobifunctional linkers that may be utilized for the preparation of ADCs with a DAR of two, three and Four in a site-specific methodology per single cysteine conjugation web site, resulting in site-specific ADCs with a DAR of 4, six and eight. The designed linkers carry a sulfhydryl-specific iodoacetyl reactive group, and a variety of cyclic diene moieties which could successfully react with maleimide-carrying payloads through the Diels-Alder response.

 

As a proof of thought, we synthesized site-specific DAR 4, six and eight ADCs carrying tubulysin (AZ13601508) using engineered antibodies with a cysteine inserted after place 239 throughout the antibody CH2 space.

 

We evaluated and in distinction the in vitro cytotoxicity of ADCs obtained by means of the site-specific platform described herein, with ADCs prepared using classical cysteine conjugation. Our data validated a novel cysteine-based conjugation platform for the preparation of site-specific ADCs with extreme  load for therapeutic functions.

New Insights into Potocki-Shaffer Syndrome: Report of Two Novel Circumstances and Literature Overview

Potocki-Shaffer syndrome (PSS) is a uncommon non-recurrent contiguous gene deletion syndrome involving chromosome 11p11.2. Present literature implies a minimal area with haploinsufficiency of three genes, ALX4 (parietal foramina), EXT2 (a number of exostoses), and PHF21A (craniofacial anomalies, and mental incapacity).
The remainder of the PSS phenotype continues to be not related to a selected gene. We report a scientific evaluate of the literature and included two novel instances. As a result of deletions are extremely variable in dimension, we outlined three teams of sufferers contemplating the PSS-genes concerned. We discovered 23 full PSS instances (ALX4, EXT2, and PHF21A), 14 instances with EXT2-ALX4, and three with PHF21A solely. Among the many latter, we describe a novel male little one exhibiting developmental delay, café-au-lait spots, liner postnatal overgrowth and West-like epileptic encephalopathy.
We recommend PSS instances could have epileptic spasms early in life, and PHF21A is more likely to be the causative gene. Given their refined presentation these could also be neglected and if left untreated might result in a extreme sort or deterioration within the developmental plateau. If our speculation is appropriate, a well timed remedy could ameliorate PSS phenotype and enhance sufferers’ outcomes. Our evaluation additionally reveals PHF21A is a candidate for the overgrowth phenotype.

Mouse Monoclonal Calcitonin antibody
MBS5305329-5x025mg 5x0.25mg
EUR 1350

Mouse Monoclonal Calcitonin antibody
MBS5305330-025mg 0.25mg
EUR 335

Mouse Monoclonal Calcitonin antibody
MBS5305330-5x025mg 5x0.25mg
EUR 1350

Mouse Monoclonal Calcitonin antibody
MBS5305331-025mg 0.25mg
EUR 415

Mouse Monoclonal Calcitonin antibody
MBS5305331-5x025mg 5x0.25mg
EUR 1705

Mouse Monoclonal Calcitonin antibody
MBS5305332-05mg 0.5mg
EUR 595

Mouse Monoclonal Calcitonin antibody
MBS5305332-5x05mg 5x0.5mg
EUR 2525

Mouse Monoclonal Calcitonin antibody
MBS5305333-05mg 0.5mg
EUR 595

Mouse Monoclonal Calcitonin antibody
MBS5305333-5x05mg 5x0.5mg
EUR 2525

Monoclonal Antibody to Calcitonin (CT)
MAA472Ra21 100ul
EUR 253

Monoclonal Antibody to Calcitonin (CT)
MBS2090546-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Calcitonin (CT)
MBS2085844-INQUIRE INQUIRE Ask for price

Calcitonin (CT) Monoclonal Antibody (Rat)
4-MAA472Ra21
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  • 100ul
  • 10ml
  • 1ml
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT)

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-5x1mL 5x1mL
EUR 2455

Mouse Anti Rat Calcitonin Receptor Monoclonal Antibody
CABT-49691MR 0.1 mg
EUR 1070.4

Calcitonin (CT) Monoclonal Antibody (Human)
4-MAA472Hu22
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  • 100ul
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT)

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Mouse Anti Human Calcitonin Receptor Monoclonal Antibody
CABT-48598MH 0.1 mg
EUR 920.4

Mouse Anti Human Calcitonin Receptor Monoclonal Antibody
CABT-48599MH 0.1 mg
EUR 920.4

Mouse Monoclonal Calcitonin antibody (Biotin)
MBS5305334-05mg 0.5mg
EUR 595

Mouse Monoclonal Calcitonin antibody (Biotin)
MBS5305334-5x05mg 5x0.5mg
EUR 2525

Calcitonin (Calcitonin (CALCA)) mouse monoclonal antibody, clone OTI2F5 (formerly 2F5)
TA190005 100 µl Ask for price

Calcitonin (CT) Monoclonal Antibody (Rat), PE
4-MAA472Ra21-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with PE.

Calcitonin (CT) Monoclonal Antibody (Rat), APC
4-MAA472Ra21-APC
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  • 100ul
  • 10ml
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with APC.

Calcitonin (CT) Monoclonal Antibody (Rat), Cy3
4-MAA472Ra21-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with Cy3.

Calcitonin (CT) Monoclonal Antibody (Rat), HRP
4-MAA472Ra21-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with HRP.

Calcitonin (CT) Monoclonal Antibody (Human), PE
4-MAA472Hu22-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with PE.

Calcitonin (CT) Monoclonal Antibody (Rat), FITC
4-MAA472Ra21-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with FITC.

Calcitonin (CT) Monoclonal Antibody (Human), APC
4-MAA472Hu22-APC
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with APC.

Calcitonin (CT) Monoclonal Antibody (Human), Cy3
4-MAA472Hu22-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with Cy3.

Calcitonin (CT) Monoclonal Antibody (Human), HRP
4-MAA472Hu22-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with HRP.

Calcitonin (CT) Monoclonal Antibody (Human), FITC
4-MAA472Hu22-FITC
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  • 100ul
  • 10ml
  • 1ml
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with FITC.

Calcitonin (CALCA) mouse monoclonal antibody, clone 42
4PC47-42 1 mg Ask for price

Mouse Anti-Human Calcitonin monoclonal antibody, clone JID632
CABT-L2980-100uL500uL 100 uL, 500 uL
EUR 602.4

Mouse Anti-Human Calcitonin monoclonal antibody, clone JID632
CABT-L2980 100 µl, 500 µl Ask for price
Description: Mouse

Monoclonal mouse anti-human calcitonin
MBS660034-10mg 10mg
EUR 4640

Monoclonal mouse anti-human calcitonin
MBS660034-15mg 15mg
EUR 6535

Monoclonal mouse anti-human calcitonin
MBS660034-1mg 1mg
EUR 655

Monoclonal mouse anti-human calcitonin
MBS660034-25mg 25mg
EUR 10285

Monoclonal mouse anti-human calcitonin
MBS660034-5mg 5mg
EUR 2505

Calcitonin (CALCA) mouse monoclonal antibody, clone 13B9
4C10-13B9 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 13F2
4C10-13F2 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 14A2
4C10-14A2 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 16B5
4C10-16B5 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 24B2
4C10-24B2 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 18B7
4PC47-18B7 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 27A3
4PC47-27A3 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 44D9
4PC47-44D9 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 6F10
4PC47-6F10 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 13G11
4C10-13G11 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 14C12
4PC47-14C12 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 22A11
4PC47-22A11 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 38F11
4PC47-38F11 1 mg Ask for price

Calcitonin (CT) Monoclonal Antibody (Rat), APC-Cy7
4-MAA472Ra21-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with APC-Cy7.

Calcitonin (CT) Monoclonal Antibody (Rat), Biotinylated
4-MAA472Ra21-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with Biotin.

monoclonal anti-Human Calcitonin (CT) IgG
CT12-M 100 ug
EUR 578.4

Mouse Anti Rat Calcitonin Receptor (C1b Isoform) Monoclonal Antibody
CABT-49689MR 0.1 mg
EUR 1070.4

PE-Linked Monoclonal Antibody to Calcitonin (CT)
MBS2042763-INQUIRE INQUIRE Ask for price

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